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23andMe demo at D6 People pay for this

29 Jul 2010

As more of the human genome is decoded, the 23andMe service will continue to get more useful, especially in regards to health care issues like drug allergies.

Linda Avey and Anne Wojcicki of the genetic testing service 23andMe gave a perplexing demo this morning at the D6 conference. The service, launched last November, costs users $1,000 ($599 with current discounts) and provides a growing amount of information based on your genetic profile: predisposition to certain diseases, a profile of your overall racial makeup, and your relationship to another genetic profile in the database if you have access to it (it will tell you if you’re related to your father, for example).

The growth of genetic testing like this for more people is inevitable, and the price will continue to drop. If you want your genome sequenced but don’t want to spend this kind of dough for it, just hang tight.

(Credit:
Dan Farber / CNET)

Click here for full coverage of the D: All Things Digital conference.

The service is still too expensive to generate reliable, broad-based data, but the new direction opens up 23andMe to research grants that can be applied to collecting genetic information from people who would otherwise not participate in the service.

23andMe has sequenced Rupert Murdoch's genome. Lactose intolerance: negative. Presence of freckles: positive.

23andMe co-founders Linda Avey and Anne Wojcicki

Today at D6, Avey and Wojciki announced the service’s new “Gene journal” feature, which lets users refine their data by answering questions that indicate broader genetic trends, such as lactose intolerance and a like or dislike of foods like cilantro. The team also showed a cute 10-question quiz that you can use to compare your genetic profile to others. This part of the demo was perplexing: if you pay $600 or $1000 for a genetic test, why should you also have to take a quiz?

(Credit:
Dan Farber / CNET)

See also:
The cheek is in the mail: Ancestry launches DNA testing

DNA dating site predicts chemical romance

At the tail-end of the presentation, Avey and Wocjciki discussed their company’s new project, 23andWe, a new research platform based on the 23andMe genetics data. The idea is that users fill out surveys (which, I guess, earlier quizzes on the site have softened them up for), which are correlated with the genetics, and which can be used for medical research. Surveys could be created by researchers and end up getting peer-reviewed, or could be set up by concerned groups on the service, like parents of children with particular syndromes.

Jackson Pollock’s hi-fi A work of art

29 Jul 2010

I visited the Pollock-Krasner House & Study Center last week in East Hampton, New York. While I was there learned the abstract expressionist Jackson Pollock and his wife, artist Lee Krasner had a pretty cool hi-fi.

Yes, I was there for the art but then I noticed the horn speaker under the stairwell to the second floor of the house. Helen Harrison, the Pollock-Krasner House’s Director allowed me to open the door and examine the speaker system in greater detail. She told me the hi-fi was purchased by Pollock in 1954. In the room behind the staircase I spotted a Bogen DB-20 tube amplifier and a Crown (?) turntable I’ve never seen before. Ms. Harrison assured me the hi-fi still works, but the records that were on hand weren’t playable. Oh well.

The Pollock-Krasner House & Study Center.

(Credit:
Steve Guttenberg)

Ms. Harrison explained that Pollock loved to play his hi-fi really loud, especially when Krasner was out of the house. Some things never change.

Pollock’s paintings now hang in museums, but it wasn’t until a 1949 article in Life magazine made him famous that his career took off (he had been painting since the 1930s). According to Google, “In November 2006 Pollock’s ‘No. 5, 1948′ became the world’s most expensive painting, when it was sold privately to an undisclosed buyer for the sum of $140,000,000. The previous owner was film and music-producer David Geffen.” While Pollock was alive he never sold a painting for more than $8,000.

The Audiophiliac ogles Pollock's hi-fi.

(Credit:
Steve Guttenberg)

(Credit:
Steve Guttenberg)

Left, inside the speaker/door; right, outside view.

Pollock’s studio is well preserved and you can see more of his dribbles and splatters all over the floor. If you’re interested in visiting the Pollock-Krasner House & Study Center check the website for more info.

When I returned home I immediately rented Ed Harris’ Pollock biopic DVD, where he played the tortured master. There’s no reference to the hi-fi per-se, other than when in a fit of anger he stops a 78 RPM record from playing. The film’s exterior shots were filmed at the Pollock-Krasner House & Study Center.

It’s also interesting that the inside of the door that supports the horn and woofer originally came from Pollock’s studio, which is a separate building from the house. The inside of the door is covered with Pollock’s trademark paint splatters, drips, and blobs, probably made while making some of his more famous paintings. That discovery stopped me in my tracks.

SAP meltdown keeps Levis jeans off the shelf

29 Jul 2010

This is the second massive SAP mishap this year. First was Waste Management’s lawsuit for $100 million, and now Levi’s couldn’t ship product for an entire week.

From guardian.co.uk

Gavin at The Reg caught this story last week but I just saw it on The Guardian. Where’s the link, Guardian?

But what Levi’s was unprepared for was the fact that the company’s IT operation could not get its multiyear, multimillion dollar investment in SAP’s business software to work optimally.

The situation became so bad that early in the second quarter, the system was shut down completely for a week. On a conference call a few days ago to announce a 98 percent drop in second-quarter profitability, CEO John Anderson said the computer disaster was a “substantial” factor in a 19 percent decline in U.S. sales and the subsequent profit meltdown.

After a sales and profitability comeback in 2007, the jeans maker was confident going into a tough 2008 that, despite a global slowdown, progress would continue.

Intel Centrino 2 launch was not about the processo

29 Jul 2010

“We are already shipping integrated graphics and you will see integrated graphics on the shelf in the coming weeks,” said Mooly Eden, general manager of Intel’s Mobile Platforms Group, speaking at the Centrino 2 launch in San Francisco. This is a departure from previous Intel statements.

The Intel WiMAXWiFi Link 5350 silicon will be available for Centrino 2 laptops “in the second half of 2008,” according to Intel.

On the gaming front, Intel announced that in addition to a new X9100 Extreme mobile processor (3.06GHz) shipping now, the first quad-core mobile processor will be available within 90 days.

Intel chipsets with integrated graphics and other chipsets that support separate “discrete” graphics chips will ship in as many as 250 laptops, Eden said.

AMD has something very similar already called “ATI PowerXpress Technology” that provides high-performance discrete graphics when plugged into a power source, then dynamically switches to integrated graphics when unplugged, saving up to 90 minutes of battery life, AMD claims.

Advanced Micro Devices would chime in here and say that it has doubled the number of “all AMD” (AMD processors, chipsets, and graphics) laptops with its Puma platform. “The key thing is we’re in market today via Puma,” said Pat Moorhead, vice president of Advanced Marketing at AMD. (More counterpoints here at Moorhead’s blog.)

HP 6730b Centrino 2 business notebook

Then there’s WiMax. A sore subject with Intel–Eden referred to “vicious rumors” about WiMax. Though Intel is still a bit cagey about the launch of the WiMax infrastructure, Eden brought out Barry West, chief technology officer of Sprint Nextel and president of the company’s new WiMax division, Xohm Networks, to talk about the upcoming WiMax launch in Baltimore, Maryland in September with “150 plus sites.”

The focus of the Centrino 2 launch returned repeatedly to the chipset and accompanying silicon: namely, the Intel 4 Series Express chipset and 802.11n and WiMax wireless chips. And if Intel can be believed, shipments of the Centrino 2 integrated graphics silicon–”GM” chipsets–have already begun and systems may be available as early as the end of this month.

(Credit:
Intel)

**X9100 will be followed by the first quad-core mobile processor “within 90 days.”

Finally, Intel showed a desktop “Montevina” design. that wasn’t much bigger than a cigar box.

*The P prefix indicates a 25-watt thermal envelope, T series is 35 watts, and X “Extreme” series is 45 watts.

Intel Switchable Graphics

Though Eden touted 1.7X better 3DMark performance, and a host of other improved benchmarks over the previous Centrino platform, he spent most of the time Monday talking about features of the Centrino 2 chipset, including hardware accelerators for playback of Blue-ray video (the ability to view a two-hour Blue-ray movie on a typical laptop battery), faster transcoding (converting, for example, audio from one format to another), and Intel “Switchable Graphics,” which allows the turning off and on of a discrete graphics chip. The latter is a power-saving feature because integrated graphics uses less power than a higher-performance discrete graphics chip from Nvidia or AMD-ATI.

There was relatively little said Monday at the Centrino 2 launch about new processors. Almost as little as was said about side shows such as a “Montevina” desktop design. The main attraction was the Centrino 2 chipset.

Why? There’s not a whole lot that’s new about the processors other than faster speeds and improved power efficiency: the new “P” series chips have a thermal envelope of 25 watts versus 35 watts for the previous generation.

(Credit:
Intel)

Intel Centrino 2 processor pricing as follows*: –X9100** (3.06GHz): $851.
–T9600 (2.8GHz): $530 –P9500 (2.53GHz): $348 –T9400 (2.53Ghz): $316 –P8600 (2.4GHz): $241 –P8400 (2.26GHz): $209

Orphan Works Half a loaf

29 Jul 2010

In addition, there are special and vexing problems surrounding visual works, such as photos, and the CO is charged with establishing an electronic database to help here, a responsibility that it does not want.

Both houses of Congress are now considering legislation to ease access to “orphan works”–material under copyright for which an owner either cannot be identified or cannot be found (HR5889 & S2913).

As a practical matter, requiring advance permission is a deal killer as far as orphan works go. Publishers can go out of business, so even the title page may not tell someone where to go for permission. Then there are tons of “gray literature” materials that may be under copyright, since everything is under copyright, but that were not produced for direct commercial purposes and are sometimes of uncertain provenance. (For example, a collection of old theater programs, or auction house catalogs, or corporation annual reports.) There are also zillions of works with no serious commercial value for which an owner might be delighted simply to see them returned to the light of day, or for which the value is too paltry to be worth the transaction costs of negotiating a fee.

Editor’s note: We’re opening up our pages today to a guest post from James V. DeLong from the Convergence Law Institute. He is also special counsel at Kamlet Shepherd and Reichert.

At some point, some kind of grand grandfathering proceeding will probably be required, a window in which holders of existing rights must reaffirm them or lose them. Otherwise, we will get the worst of all worlds; much material will lie fallow and neglected, while other works will simply be digitized regardless. The ‘Napsterization’ of the music industry that resulted from the slowness of the rights holders to get ahead of the curve of digital distribution should be a cautionary tale.

These are good proposals. Not problem-free, but good, and long overdue, so one should wish them bon voyage. One can argue that they are unnecessary because any use that follows a vain search for a copyright owner should be automatically protected as “fair,” but commercial organizations, looking down the barrel of heavy statutory damages, do not want to test this proposition.

This is where the technology is going, and the law will have to adapt. It is a truism of history that protecting property rights is crucial, but the exact forms they take are malleable, according to the technological and economic realities of the time. Today is no different.

These possibly-orphan, sort-of-orphan, and gray literature works simply cannot be made available if the digitizers are required to make one-by-one judgments and seek permission before copying. If they are to be retrieved in useful form, then sooner or later Google, Amazon, Microsoft, and some others must be permitted to digitize on a massive scale.

So the orphan works bills are a good start, Congress, but we should already be working on the next round.

Finding a solution will not be easy, of course. There are problems with definitions, graphic works, audio works, visual works, the need to provide incentives for people to find gold in the dross of past materials, and more.

Both bills are based on the Copyright Office proceeding of a couple of years ago, and their basic structures embody the CO-recommended solution. If someone wants to use a work, he/she must conduct a diligent search for an owner. If no owner can be found, then the work can be used. If an owner turns up later, a reasonable fee will be paid, based on a “willing buyer, willing seller” standard. The CO gets to define standards for reasonable searches, relying on best practices developed by the relevant communities.

The bills are good, but they solve only part of the problem: they help users who already knows what material they lust after. They do not help users search through the vast existing archives to find material worthy of such lust, and more legal tinkering is going to be needed.

These efforts raise some legal problems. Publishers object on the grounds that making a digital copy is itself an infringement, especially if the copy is then shared with a library that may have expansive ideas of its rights to disseminate it further. They suggest that digitizers must get the copyright owner’s permission first, and they may well be right to claim this is legally necessary. Google is temporizing by continuing the scanning program while being careful to limit public access to anything under copyright, but lawsuits against even this are pending.

But what if a user does not know what he or she wants to use, and needs to search to find out? This is the need addressed by Google and other companies that want to shovel whole libraries through the maws of the scanners, making them available for search and retrieval.

On the other hand (and one needs a lot of hands to really discuss this issue), it is important that digitization not deprive intellectual property owners of legitimate rights, and how one writes a law that allows digitization by the reputable without also enabling Piracy, Inc., or Carelessness Corp. is a tough question.

There is also a need to allow digital access as well as search. As an Amazon Kindle user-tending-toward-addict, I find Google Book Search a bit irritating. I do not want to know where to buy a hard copy of the book; I want it now. Or, even better for research purposes, I want to buy a copy of a few selected pages online, not the whole work.

Why the Wii is well-suited to video game violence

29 Jul 2010

As to whether or not game developers will make violent games for the Wii and if they will be big sellers is not my area of expertise. It’s the underlying possibilities of the technology that I find interesting.

2. The Wii brings a whole new level of human/game interaction that would be well suited to more adult/violent games
       a. Wii baseball has a batting game. I’m not suggesting this is the same social context as hitting some in-game enemy in the head, but I am saying it’s pretty fun to hit stuff.
       b. We all need more exercise

I wrote recently about the need for violent video games on the Nintendo Wii and, for clarity, the main point of my message is that the
Wii is a great platform for a game that has physical interaction.

1. Nintendo wants to sell more Wiis and games. Hardcore gamers are not buying Wiis
       a. I could make a couch-jockey/carpal tunnel joke, but the Wii doesn’t have the graphics horsepower of other consoles or PCs. What it does have is the ability to use more than your thumbs to play a game.

The comments and arguments around my previous post (in which I assert violent video games are cool) remind me of the Simpsons episode when Marge campaigns against Itchy and Scratchy.

Violent video games on the Wii address two specific points:

I don’t know if video game violence has an effect on children, and I’m not sure if I care. I write about software disruption, not social issues.

It could be where you can pull a street sign from the ground and shove it into your enemy’s head, or it could be a cooking game where you have to assemble a Gordon Ramsay-esque 10-course meal. The point is, the Wii has unique features that are well suited to violent games.

I figure if you can do one thing (hit a baseball) then you can do more things (hit an in-game enemy in the head). How that gets manifested into the game is a whole different story.

Energy Dept. aims to give out stimulus loans by su

29 Jul 2010

Chu said he could not parse out specifically how much of that energy will come from which sources, but he said there are a few mature renewable sources that could help the country reach that goal, such as wind and photovoltaic energy.

“We have undergone a detailed scrubbing of the process,” he said. “What we’ve found is that the old process required too much paperwork and simply took too long. These are sweeping reforms in the way the Department of Energy does business.”

Among other things, the department also intends to establish a Web site to provide more assistance to applicants and add transparency to the process.

Steven Chu, now secretary of the Department of Energy, at his former lab at Stanford University.

“If you look at some of the wealth creation in the United States–the Internet, biotech–a lot of that was driven by companies that deeply believed in research like Bell Laboratory, IBM Labs,” he said. “In the energy sector, you don’t have that. What I see is the Department of Energy filling that vacuum.”

He also said he meets with White House climate czar Carol Browner and Environmental Protection Agency Administrator Lisa Jackson about once a week to make sure the Energy Department’s interests do not conflict with the White House’s climate change goals.

“It’ll be interesting to see what the market brings forward,” Rogers said Thursday.

To get the money out more quickly, Chu announced Thursday he is naming Matt Rogers as a senior adviser to implement the new department reforms. Rogers formerly served as a senior partner at McKinsey and worked with the energy industry for more than 20 years. He also served on the Obama transition team.

WASHINGTON–Energy Secretary Steven Chu announced on Thursday a number of ways he will streamline the process by which the Energy Department distributes funding, with the goal of dispersing 70 percent of its funds from the American Recovery and Reinvestment Act by the end of 2010.

As the department works to develop the renewable energy sector, Chu said it is imperative it also fund basic science research.

The energy investments in the stimulus package intimately tie the reshaping of the energy sector to the country’s economic recovery.

The department will also be working with outside industries to find good projects to finance.

Chu said as the government tries to accelerate the use of renewable energies, it will also be exploring different methods of carbon capture and sequestration.

“Right now, to the best of my knowledge, it is not a slam dunk which technology is the right one,” he said.

The changes Rogers will implement include rolling out appraisals of applications for loan guarantees, rather than waiting for the application deadline to evaluate them. Loan application forms will be simplified and the department will speed up loan underwriting by using outside partners.

With these changes in place, the department should be able to begin offering loan guarantees under its previous loan guarantee program by late April or early May, Chu said, though some recipients may have to secure their own share of the financing or meet other conditions before their applications are approved. With the same financing conditions, the department should be offering loan guarantees under the stimulus legislation by early summer, Chu said.

Chu called the significant investment “very farsighted.”

“The goal is to begin making these investments in months, not years,” Chu said.

“There are numerous wind projects that can go forward,” he said. “The Bonneville Power Administration has (transmission) lines sited and those lines will connect to wind farms. This is something that can be done within this two-year period.”

When President Obama signed the American Recovery and Reinvestment Act on Tuesday, he said the bill should allow the country to double its use of renewable energy within three years.

(Credit:
Stanford University)

Give the Jobs cancer story a rest

27 Jul 2010

Unfortunately for Apple, people remember that the company’s board failed to immediately disclose Jobs’ original cancer diagnosis. (Fortune Magazine reported that the board held onto the news for nine months before disclosing it to shareholders.) So now the rumor mill is churning out speculation aplenty–just in case.

“Many readers will consider this post inappropriate,” Blodget began. He should have taken that advice to heart and stopped right there.

Sideline diagnoses aren’t worth much, and I don’t buy this nonsense that the public has any special rights here. If Jobs no longer can carry out the function of a CEO, he should turn over the reins to a successor. Until then, it’s a private matter for Jobs and his family.

Enough already. It’s beyond bad form.

(Credit:
James Martin/CNET News.com)

Maybe it’s our particular infatuation with Apple and its mercurial co-founder, or maybe it’s simply a by-product of the times we live in, where seemingly nothing is out of bounds for public discussion. Whatever the reason, I surely can’t be the only person reacting to the “Is Steve having a cancer relapse” rumor with a fix of frustration and disgust.

Yesterday, Valleywag speculated about Jobs’ health and this morning Henry Blodget is running his mouth.

Truth be told, I did wonder whether Jobs had suffered a relapse when I saw his interview with CNBC yesterday. He looked thin, even gaunt. But last time I checked, neither Apple nor its CEO had issued a health alert.

EU directive could change iPhone battery design

23 Jul 2010

Getting at the iPhone 3G's battery is not as easy as a proposed directive from the E.U. might require.

Still, the proposed wording does require that cell phone batteries be designed in such a way as to be “readily removed,” according to New Electronics. As these teardown photos from our friends at Tech Republic show, that’s not the case with the iPhone.

AppleInsider spotted that particular directive in an article in New Electronics, a U.K. trade publication, on the latest set of computer-industry regulations under consideration in Europe. The EU is thinking about enacting a new directive on batteries similar to its RoHS (Reduction of Hazardous Substances) directives from a few years back that forced the computer industry to eliminate harmful chemicals and/or materials from its manufacturing processes.

The “New Batteries Directive” would require manufacturers to make sure their batteries can be easily replaced, either by sliding off the cover or removing a couple of screws. The iPhone and iPod, of course, don’t fit that mold; Apple requires owners to send their iPhones and iPods into the company to replace the battery, which is buried under the main circuit board.

(Credit:
TechRepublic)

It’s not clear that the directive–which is very vaguely worded at present–would force drastic changes in the design of the iPhone. As AppleInsider notes, the idea behind the directive is to prevent batteries from ending up in landfills, and if Apple is able to show the E.U. that its battery replacement program prevents that result, that might meet the requirements of the directive.

The European Union is considering a requirement that all cell phone batteries be easily replaceable, which might cause a problem for Apple’s
iPhone.

GoAnimate puts powerful animation tools in your br

20 Jul 2010

(Credit:
CNET Networks)

The tool also feels a little cramped on larger screens as it doesn’t scale to match the extra width. This, too, is a small quibble, but after having played with Flash game creator PlayCrafter yesterday (story), tools that account for this extra space make it far easier for people who are serious about using them as an alternative to desktop applications.

GoAnimate lets you stick cropped heads onto ready-made animated characters quickly and easily. The results can be rather humorous.

GoAnimate is completely free to use. You can see an example of the test one I made here.

GoAnimate is a browser-based animation studio. It lets you build multi-scene animated creations, complete with support for music, transitions, and user-uploaded page elements. I spent most of this morning playing around with it and the results are about on par with what you’d find on one of those animated greeting cards.

One cool feature is that you can upload pictures from your hard drive, Facebook, or Flickr and turn them into props, backgrounds, or human heads. These heads can be stuck onto the bodies of pre-made characters, so with just a few head shots you can make your very own animated faces by splicing scenes together.

Like most video editing applications GoAnimate centers around a time line. Everything is drag and drop, so you can pick out characters, props, backgrounds and special effects and simple put them on the canvas where you see fit. Each “scene” can be edited to last as long as you want, and you can drag finished scenes around the time line to re-order them. Basically everything is set up to let you quickly clone and continue your work with minimal effort.

While simple to use, the tool is not without its shortcomings. For instance, you can’t set up several character movements or actions within one scene. This means attaching a speech bubble to a character requires its own scene instead of being able to time out multiple speech bubbles in one scene using delay. I know this seems like a small quibble, but it means adding in more scenes when you could simply mark out the action on a separate time line.

The short I made consisted of nine scenes and took about a half hour to make, however most of that was me learning how to use the tool. Part of the process is picking out ready made characters and customizing them which is fairly intuitive and similar to working on a Microsoft PowerPoint presentation. As the author you can move objects up and down, and program in things like automated object movement and transitions.